Data, reagents, assays and merits of proteomics for SARS-CoV-2 research and testing

Prof. Dr. Bernhard Küster
Prof. Dr. Bernhard Küster

TUM School of Life Sciences Weihenstephan
Technical University of Munich
Emil-Erlenmeyer-Forum 5
85354 Freising, Germany

Hospitals involved

Type of analysis

In Brief

As the COVID-19 pandemic continues to spread, research on SARS-CoV-2 is also rapidly evolving and the number of associated manuscripts on preprint servers is soaring. To facilitate proteomic research, Zecha et al. present protein expression profiles of four model cell lines and investigate the response of Vero E6 cells to viral infection. Further, they evaluate the feasibility of proteomic analysis for SARS-CoV-2 diagnostics and critically discuss the merits of proteomic approaches in the context of the COVID-19 research.

Highlights

  • In-depth proteomes of 4 SARS-CoV-2 cell line models (Vero E6, Calu-3, Caco-2, A549)
  • Proteomic evidence for thousands of Chlorocebus sabaeus proteins
  • Proteomic response of Vero E6 cells to SARS-CoV-2 infection
  • Synthetic peptides, spectral libraries and targeted assays for SARS-CoV-2 proteins

Outputs

Publication

MCP

Protocol used

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Processed data

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